Table 4.
GH in First and/or Second Pregnancy and Risk of CVD Among 421 770 Women With at Least 2 Pregnancies Followed From 1980 to 2009 (Cohort 2)
| No./Events | HR (95% CI)a | |
|---|---|---|
| No HPD, no SGA, no preterm deliveryb | 302 623/8828 | 1 |
| GH only | ||
| First, but not second pregnancy | 4901/254 | 1.7 (1.5–2.0) |
| Second, but not first pregnancy | 2646/180 | 2.4 (2.1–2.8) |
| Both pregnancies | 543/32 | 1.9 (1.3–2.6) |
| GH and SGA and/or preterm delivery | ||
| First, but not second pregnancy | 1139/71 | 2.0 (1.6–2.5) |
| Second, but not first pregnancy | 418/39 | 3.0 (2.2–4.1) |
| Both pregnanciesc | 230/26 | 3.6 (2.4–5.2) |
Cox proportional hazard regression analyses with mother's age as the time scale. Follow‐up starts at mother's age at second delivery. Women with preeclampsia are excluded from the analysis (n=24 026). Category with other combinations of gestational hypertension (GH)/small‐for‐gestational‐age (<10th percentile) (SGA) infant/preterm not shown (n=85 244). CI indicates confidence interval; CVD, cardiovascular disease; HPD, hypertensive pregnancy disorder; HR, hazard ratio; preterm delivery, <37 weeks of gestation.
Adjusted for educational level, marital status, and birth year of first child (all are significant in full model).
No GH, preeclampsia, SGA, or preterm delivery in first or second pregnancy.
GH in both pregnancies, SGA/preterm in at least 1 pregnancy.