Figure 1. Tools for deriving a spatiotemporal multi-scale model of the human pancreatic β-cell.
Methods of interest: Fluorescent imaging (super-resolution imaging, live imaging), X-ray tomography, cryo-electron tomography, genome architecture mapping (Hi-C maps, fluorescent in-situ hybridization, etc.), integrative structure modeling, protein structure determination (X-ray crystallography, electron microscopy, nuclear magnetic resonance spectroscopy), omics (proteomics, transcriptomics, metabolomics, genomics, lipidomics), computational systems biology, and molecular graphics and packing tools. These methods collectively cover a wide range of scales from atomic to the cellular level. Images were adapted from (Kalhor et al., 2011; Xu et al., 2015) (Jeong et al., 2001; Liu et al., 2012; Sali et al., 2015; Song et al., 2017; Yang et al., 2015)