Table 4.
Allele and genotype frequencies of rs1805124 polymorphism in SCN5A gene, in FDC, and IDC patients versus controls and their association with dilated cardiomyopathy risk
| Allele frequencies | Genotype frequencies | |||||||||
| Individual groups | N | % | P* | N | % | P* | OR (95% CI) | P | ||
| FDC (n = 56) | A | 68 | 60.7 | 0.0005 | AA | 23 | 41.1 | <0.0001 | 1.0a | |
| AG | 22 | 39.3 | 2.22 (1.15–4.26)b | 0.017b | ||||||
| G | 44 | 39.3 | GG | 11 | 19.6 | 7.39 (2.88–18.96)c | <0.0001c | |||
| IDC (n = 79) | A | 119 | 75.3 | 0.15 | AA | 46 | 58.2 | 0.076 | 1.0a | |
| AG | 27 | 34.2 | 1.48 (0.86–2.55)b | 0.161b | ||||||
| G | 39 | 24.7 | GG | 6 | 7.6 | 2.01 (0.71–5.74)c | 0.189c | |||
| Controls (n = 251) | A | 410 | 82 | AA | 170 | 67.7 | ||||
| AG | 70 | 27.9 | ||||||||
| G | 92 | 18 | GG | 11 | 4.4 | |||||
Significant P values are shown in italic bold.
CI, confidence interval; DCM, dilated cardiomyopathy; FDC, familial dilated cardiomyopathy; IDC, idiopathic dilated cardiomyopathy; OR, odd ratio; P*, Pearson Chi-square test between patients versus controls; P, Logistic regression analysis.
aAA genotype as Reference group.
bAG genotype versus Reference group.
cGG genotype versus Reference group.