Figure 2. TET2 expression is downregulated in glioma.
(A) Comparison of TET2 mRNA expression levels between control brains (n = 14), gliomas (n = 7) and glioblastoma cell lines (n = 4) are shown on the left. Expression levels were determined by qRT-PCR, and data are expressed as a ratio in relation to GAPDH. Fold change was calculated relative to control samples with low expression levels. Wilcoxon signed rank test was applied. **p-value < 0.01. (B) TET2 protein levels detected by immunohistochemistry (IHC) are shown.