Figure 1.
Gross and molecular structure of the node of Ranvier in central nervous system (CNS) and peripheral nervous system (PNS). Cell adhesion molecules forms complex with other adhesion molecules, ion channels, and the cytoskeleton to form the nodal, paranodal, and juxtapranodal compartments. The main difference between the CNS and PNS nodes is the interaction partners of neurofascin 186 (NF186). The targets of the autoantibodies found in patients with seropositive chronic inflammatory demyelinating polyneuropathy are neurofascin 155, Cntn1, and contactin-associated protein 1, which altogether form a complex in the paranode (red rectangle); and NF186 that is located in the node (green rectangle) and also in the axon initial segment. Reprinted by permission from Springer Customer Service Centre GmbH: Springer Nature [COPYRIGHT] (5).