Table 2.
The number of unique synonymous amino acid substitutions and unique nonsynonymous amino acid substitutions across all isolates sequenced for this study. Individual nonsynonymous substitutions are also shown in the column on the right.
| Gene | Gene Product | Number Unique Synonymous Substitutions | Number Unique Nonsynonymous Substitutions | Nonsynonymous Substitutions |
|---|---|---|---|---|
| CIRC | myristylated tegument protein CIRC | 2 | 0 | none |
| ICP0 | ubiquitin E3 ligase ICP0 | 1 | 1 | Thr479Ser |
| ICP4 | transcriptional regulator ICP4 | 0 | 0 | none |
| UL1 | envelope glycoprotein L | 0 | 1 | Thr111Ile |
| UL10 | envelope glycoprotein M | 1 | 1 | Val142Ile |
| UL11 | myristylated tegument protein | 0 | 0 | none |
| UL12 | deoxyribonuclease | 1 | 0 | none |
| UL13 | tegument serine/threonine protein kinase | 1 | 0 | none |
| UL14 | tegument protein UL14 | 0 | 2 | Tyr167His, Ser25Pro |
| UL15 | DNA packaging terminase subunit 1 | 2 | 4 | Thr426Pro, Ala4Gly, His471Gln, Pro614Gln |
| UL16 | tegument protein UL16 | 0 | 0 | none |
| UL17 | DNA packaging tegument protein UL17 | 0 | 0 | none |
| UL18 | capsid triplex subunit 2 | 0 | 0 | none |
| UL19 | major capsid protein | 3 | 2 | Arg333Leu, Asp14Glu |
| UL20 | envelope protein UL20 | 2 | 1 | none |
| UL21 | tegument protein UL21 | 0 | 1 | Ala265Val |
| UL22 | envelope glycoprotein H | 0 | 1 | Asp723Asn |
| UL23 | thymidine kinase | 0 | 1 | Thr20Ile |
| UL24 | nuclear protein UL24 | 0 | 0 | none |
| UL25 | DNA packaging tegument protein UL25 | 0 | 0 | none |
| UL26 | capsid maturation protease | 0 | 0 | none |
| UL26.5 | capsid scaffold protein | 0 | 0 | none |
| UL27 | envelope glycoprotein B | 0 | 3 | Pro360Thr, Val627Leu, Gly940Ser |
| UL28 | DNA packaging terminase subunit 2 | 2 | 2 | Pro427Gln, Gly300Ala |
| UL29 | single-stranded DNA-binding protein | 2 | 2 | Ser1089Pro, Val483Ile |
| UL3 | nuclear protein UL3 | 0 | 0 | none |
| UL3.5 | protein V57 | 0 | 2 | Glu162Gly, Pro45Leu |
| UL30 | DNA polymerase catalytic subunit | 0 | 1 | Ile153Thr |
| UL31 | nuclear egress lamina protein | 0 | 1 | Arg53Gln |
| UL32 | DNA packaging protein UL32 | 2 | 0 | none |
| UL33 | DNA packaging protein UL33 | 0 | 1 | Phe51Leu |
| UL34 | nuclear egress membrane protein | 1 | 0 | none |
| UL35 | small capsid protein | 0 | 1 | Ser3Arg |
| UL36 | large tegument protein | 3 | 5 | Asn2936_Val2937del, Pro2838Ser, Arg3006His, Asp422Glu, Thr291Ile |
| UL37 | tegument protein UL37 | 1 | 0 | none |
| UL38 | capsid triplex subunit 1 | 1 | 2 | Ile277Met, Gly55Asp |
| UL39 | ribonucleotide reductase subunit 1 | 0 | 0 | none |
| UL4 | nuclear protein UL4 | 0 | 0 | none |
| UL40 | ribonucleotide reductase subunit 2 | 0 | 2 | Val66Ile, Pro8Leu |
| UL41 | tegument host shutoff protein | 2 | 0 | none |
| UL42 | DNA polymerase processivity subunit | 1 | 0 | none |
| UL43 | envelope protein UL43 | 0 | 0 | none |
| UL44 | envelope glycoprotein C | 0 | 1 | Lys133Glu |
| UL45 | membrane protein UL45 | 0 | 0 | none |
| UL46 | tegument protein VP11/12 | 0 | 1 | Ser666Pro |
| UL47 | tegument protein VP13/14 | 1 | 1 | Leu132Ser |
| UL48 | transactivating tegument protein VP16 | 0 | 1 | Leu132Ser |
| UL49 | tegument protein VP22 | 0 | 0 | none |
| UL49.5 | envelope glycoprotein N | 0 | 0 | none |
| UL5 | helicase-primase helicase subunit | 2 | 1 | Gly136Ser |
| UL50 | deoxyuridine triphosphatase | 0 | 0 | none |
| UL51 | tegument protein UL51 | 0 | 0 | none |
| UL52 | helicase-primase primase subunit | 0 | 2 | Tyr484Cys, Arg208Lys |
| UL53 | envelope glycoprotein K | 0 | 0 | none |
| UL54 | multifunctional expression regulator | 0 | 0 | none |
| UL55 | nuclear protein UL55 | 0 | 4 | Ile78Met, Arg93Gly, Arg108Ser, Pro116Ser |
| UL56 | membrane protein UL56 | 0 | 0 | none |
| UL6 | capsid portal protein | 2 | 0 | none |
| UL7 | tegument protein UL7 | 0 | 0 | none |
| UL8 | helicase-primase subunit | 1 | 0 | none |
| UL9 | DNA replication origin-binding helicase | 2 | 1 | Val637Met |
| US1 | regulatory protein ICP22 | 0 | 0 | none |
| US10 | virion protein US10 | 0 | 0 | none |
| US2 | virion protein US2 | 0 | 1 | His46Tyr |
| US3 | serine/threonine protein kinase US3 | 0 | 0 | none |
| US4 | envelope glycoprotein G | 0 | 1 | Ser326Asn |
| US6 | envelope glycoprotein D | 0 | 0 | none |
| US7 | envelope glycoprotein I | 1 | 1 | Met165Thr |
| US8 | envelope glycoprotein E | 0 | 2 | Ser458Pro, Arg423Cys |
| US8A | membrane protein US8A | 0 | 0 | none |
| US9 | membrane protein US9 | 1 | 0 | none |
| V1 | membrane protein V1 | 0 | 1 | Phe126fs |
| V32 | protein V32 | 0 | 0 | none |