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. Author manuscript; available in PMC: 2018 May 2.
Published in final edited form as: Nature. 2017 May 17;545(7655):495–499. doi: 10.1038/nature22396

Extended Data Figure 4. Immunocompromised mice also exhibit tumor-specific expression of PD-1 on macrophages.

Extended Data Figure 4

a. Analysis of PD-L1 overexpressing CT26/YFP+ tumors in BALB/c Rag2−/−γc−/− mice shows that TAMs specifically express PD-1 (n=4. Paired one-way ANOVA with multiple comparisons correction). b. Comparing BALB/c Rag2−/−γc−/− tumor volume vs. % PD-1+ TAMs shows a highly significant correlation between tumor volume and PD-1 expression (n=9. Best fit line is shown). c. Analysis of DLD-tg(hPD-L1)-GFPluc+ tumors shows that TAMs specifically express PD-1 (n=5. Paired one-way ANOVA with multiple comparisons correction). d. Comparing NSG tumor volume vs. % PD-1+ TAMs shows a highly significant correlation between tumor volume and PD-1 expression (n=10. Best fit line is shown). *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001; n.s., not significant. Data are mean ± s.e.m.