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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Circ Res. 2012 Sep 19;112(1):48–56. doi: 10.1161/CIRCRESAHA.112.272963

Figure 1. Gene-targeting of stress-responsive Dusp4 in the heart.

Figure 1

A, Normalized SYBR green quantitative PCR for DUSP1, DUSP4, and DUSP10 encoding mRNA from heart of mice subjected to Sham or TAC procedure for the indicated period of time in days or weeks (*P < 0.01 vs. sham; #P < 0.05 vs. sham; n=3–6 per time point). B, Schematic of the Dusp4 genetic locus and the targeting vector (T.V.) used to create Dusp4 gene-deleted mice. C, RT-PCR for DUSP1, DUSP4, and L7 (control) from hearts of control (Wt) and Dusp1/4 double null (Dusp1/4−/−) mice at 1 month of age.