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TF binding sites are more evolvable than RBP binding sites. Histograms of the distribution of evolvability for TF binding sites in (A) D. melanogaster and (B) H. sapiens and for RBP binding sites in (C) D. melanogaster and (D) H. sapiens. (E) Evolvability is shown in relation to the fractional size of the genotype network, showing that evolvability increases more rapidly with genotype network size and reaches a higher maximum value for TF binding sites than for RBP binding sites.
