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. 2018 Apr 12;8:5913. doi: 10.1038/s41598-018-24085-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inducible DNA recombination in mouse astroglia: Summary. (A) Concentrations of TAM and its derivatives after single TAM injections revealed that about 28% of the originally injected TAM could be detected in the brain while only 4% 4-OH-TAM, 6% NDM-TAM and negligible amount of END could be found at 8 hpi. While TAM (9%) and 4-OH-TAM (3%) decreased 24 hpi, NDM-TAM (9%) and END (3 × higher) increased their concentrations in the brain. (B) The optimized injection protocol for GLAST-Cre^ERT2 mice for cortical and cerebellar recombination requires TAM injections for three to five consecutive days depending on brain region and floxed allele. (C) In a brain of a young adult mouse, astrocytes account for 20% (±2, n = 14) in the bs, 8% (±2, n = 13) in the cb, 22% (±2, n = 19) in the ctx, 30% (±3, n = 16) in the hc and 31% (±2, n = 17) in the optic nerve (setting GLAST-positive cells as astrocytes).