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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Hypertension. 2018 Mar 26;71(5):804–810. doi: 10.1161/HYPERTENSIONAHA.118.10266

Figure 1.

Figure 1

Signal transduction mechanism of EGFR transactivation by AngII in vascular smooth muscle cells leading to vascular remodeling. PTK; protein tyrosine kinase, PI3K; Phosphoinositide 3-kinase, p70S6K; p70 S6 kinase. Please note that in addition to this cascade both classical and novel pathways have been shown to contribute to AngII-mediated vascular remodeling (reviewed in detail recently in the reference 31).