TABLE 4.
Multivariable-adjusted ORs (95% CIs) of the associations between dietary patterns and high plasma biomarker pattern scores1
| Dietary pattern quintile | P-trend2 | Per 1-SD increase in dietary pattern score | |||||
|---|---|---|---|---|---|---|---|
| Biomarker pattern | Quintile 1 | Quintile 2 | Quintile 3 | Quintile 4 | Quintile 5 | ||
| Western dietary pattern | |||||||
| High:low GP130-TNFR2 pattern score | 121:118 | 119:121 | 112:125 | 116:127 | 131:108 | ||
| Adjusted model | 1 | 1.05 (0.72, 1.52) | 0.93 (0.64, 1.36) | 1.03 (0.71, 1.50) | 1.30 (0.89, 1.89) | 0.24 | 1.05 (0.97, 1.14) |
| High:low TNFR2–IL-2R pattern score | 113:126 | 115:125 | 122:115 | 115:128 | 134:105 | ||
| Adjusted model | 1 | 1.05 (0.72, 1.54) | 1.07 (0.73, 1.57) | 0.93 (0.63, 1.36) | 1.35 (0.92, 1.99) | 0.28 | 1.05 (0.96, 1.14) |
| High:low CD14 pattern score | 111:128 | 113:127 | 116:121 | 123:120 | 136:103 | ||
| Adjusted model | 1 | 1.27 (0.85, 1.89) | 1.54 (1.02, 2.31) | 1.77 (1.18, 2.66) | 2.04 (1.36, 3.08) | 0.0002 | 1.19 (1.09, 1.31) |
| Prudent dietary pattern | |||||||
| High:low GP130-TNFR2 pattern score | 125:114 | 112:128 | 112:128 | 129:111 | 121:118 | ||
| Adjusted model | 1 | 0.72 (0.50, 1.04) | 0.73 (0.50, 1.06) | 0.93 (0.64, 1.36) | 0.80 (0.55, 1.16) | 0.67 | 0.98 (0.90, 1.07) |
| High:low TNFR2–IL-2R pattern score | 141:98 | 115:125 | 107:133 | 122:118 | 114:125 | ||
| Adjusted model | 1 | 0.65 (0.44, 0.95) | 0.55 (0.37, 0.81) | 0.69 (0.47, 1.01) | 0.59 (0.40, 0.87) | 0.03 | 0.91 (0.83, 0.99) |
| High:low CD14 pattern score | 119:120 | 119:121 | 117:123 | 127:113 | 117:122 | ||
| Adjusted model | 1 | 0.78 (0.52, 1.17) | 0.84 (0.56, 1.25) | 0.98 (0.65, 1.47) | 0.76 (0.51, 1.14) | 0.49 | 0.97 (0.88, 1.06) |
Values are n or ORs (95% CIs) unless stated otherwise. Dietary patterns were adjusted for energy intake using the residual method. Biomarker scores were classified as high (greater than or equal to the median score) compared with low (less than the median score). Median scores were −0.1215 for the GP130-TNFR2 pattern score, −0.0875 for the TNFR2–IL-2R pattern score, and −0.0170 for the CD14 pattern score. All analyses were adjusted for age at blood draw, sex, physical activity, smoking status, case-control status, BMI (in kg/m2), chronic disease comorbidity score, and regular use of aspirin, acetaminophen, other nonsteroidal anti-inflammatory drugs, or cholesterol-lowering drugs, as described in the Methods. GP130, soluble glycoprotein 130; IL-2R, soluble interleukin-2 receptor; TNFR2, soluble tumor necrosis factor receptor 2.
The P value for trend was the P value of the dietary pattern as a continuous variable adjusted for all covariates listed in footnote 1.