Table 2. Cerebellum Co-expression networks in the Discovery Cohort with significant cell type enrichment.
WGCNA consensus modules are generated from the Discovery Cohort’s WG-DASL transcript data obtained from the cerebellum. The remaining definitions are as per Table 1.
| Model | Module Name | Module Size | Cell Type Enrichment | Disease Association | Top GO Biological Process | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cell Type | OR | P value | Beta | P value | ID | Name | Enrichment P value | |||
| Simple | AD+PSP.CER31.CSsimple | 83 | Astrocyte | 11.0 | 5.08E-06 | 0.02 | 6.86E-01 | NA | NA | NA |
| AD+PSP.CER16.CSsimple | 288 | Astrocyte | 20.4 | 2.06E-41 | 0.07 | 2.47E-01 | GO:0007399 | nervous system development | 2.60E-04 | |
| AD+PSP.CER17.CSsimple | 239 | Microglia | 91.6 | 1.26E-139 | 0.01 | 8.24E-01 | GO:0002376 | immune system process | 1.49E-42 | |
| AD+PSP.CER12.CSsimple | 407 | Neuron | 2.4 | 4.39E-02 | −0.02 | 7.37E-01 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 2.98E-02 | |
| AD+PSP.CER4.CSsimple | 854 | Neuron | 2.9 | 5.77E-08 | −0.02 | 7.81E-01 | GO:0016070 | RNA metabolic process | 1.25E-05 | |
| AD+PSP.CER35.CSsimple | 65 | Neuron | 11.2 | 1.07E-07 | −0.03 | 6.62E-01 | GO:0048265 | response to pain | 3.56E-02 | |
| AD+PSP.CER21.CSsimple | 180 | Oligodendrocyte | 129.6 | 5.39E-72 | 0.01 | 8.51E-01 | GO:0042552 | myelination | 8.00E-08 | |
|
| ||||||||||
| Comprehensive | AD+PSP.CER13.CS | 284 | Astrocyte | 18.9 | 4.01E-37 | 0.06 | 3.10E-01 | GO:0042063 | gliogenesis | 9.54E-06 |
| AD+PSP.CER25.CS | 70 | Astrocyte | 42.6 | 1.43E-26 | 0.06 | 3.63E-01 | GO:0010634 | positive regulation of epithelial cell migration | 1.71E-03 | |
| AD+PSP.CER19.CS | 138 | Microglia | 119.9 | 2.57E-107 | 0.02 | 7.81E-01 | GO:0006955 | immune response | 2.21E-33 | |
| AD+PSP.CER3.CS | 1089 | Neuron | 2.6 | 3.87E-08 | −0.02 | 6.96E-01 | GO:0016071 | mRNA metabolic process | 3.86E-07 | |
| AD+PSP.CER6.CS | 703 | Neuron | 2.4 | 1.24E-03 | 0.01 | 8.77E-01 | GO:0007399 | nervous system development | 2.42E-02 | |
| AD+PSP.CER23.CS | 92 | Neuron | 13.0 | 3.69E-13 | −0.03 | 5.96E-01 | GO:0007268 | synaptic transmission | 4.39E-05 | |
| AD+PSP.CER20.CS | 131 | Oligodendrocyte | 149.4 | 3.37E-66 | 0.003 | 9.66E-01 | GO:0042552 | myelination | 1.31E-09 | |