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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Alzheimers Dement. 2017 Oct 31;14(3):352–366. doi: 10.1016/j.jalz.2017.09.012

Fig. 1. Volcano plots of fold change vs. significance for differential gene expression (DGE) in the temporal cortex (TCX).

Fig. 1

Results are shown for the primary analysis of AD vs. PSP TCX DGE in the Discovery Cohort, under the Simple (A0–A9) and Comprehensive (B0–B11) models. Each circle represents a transcript, which are colored differently according to the CEM they pertain to. Transcripts with strong module membership (MM) values≥0.7 are shown as filled circles; or empty circles if MM<0.7. Results are shown for all transcripts analyzed (A0, B0) and also separately for those CEM with consistent brain cell-enrichment across both models. DGE results that are significant at q≤0.05 or q≤0.01 are shown above the green and red dotted lines, respectively.