Table 3.
The impact on major depressive disorder (MDD) is displayed for polygenic risk scores (PRS) and their interaction with the childhood trauma (CT) dichotomous indicator covering sexual abuse and physical abuse (broad definition). The prevalence of CT is presented in MDD cases, controls, and in terms of the full population (Pop) assuming a population prevalence of MDD of 15% with twice the prevalence in females (20%) as in males (10%). The impact of the PRS and CT is presented as the odds ratio (OR) from logistic regression corrected for sex and three principal components, as well as with the variance explained by the PRS on the liability scale. Interaction of PRS with CT (PRSxCT) was assessed as departure from multiplicativity with logistic regression while additionally correcting for the main effects of PRS and CT. The PRS were based on discovery GWAS results from MDD including all SNPs, i.e. with significance threshold p<1.
| Impact on MDD
|
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|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N
|
Proportion exposed to CT
|
CT
|
PRS
|
PRSxCT
|
||||||||
| Cohorts | Case | Control | Case | Control | Pop | OR | P | OR | P | R2 (SE, %) | OR | P |
| COFAMS | 56 | 22 | 0.43 | 0.27 | 0.30 | 1.85 | 0.268 | 1.41 (0.82:2.49) | 0.212 | 3.13 (4.61) | 0.51 (0.21:1.05) | 0.088 |
| DGN | 461 | 458 | 0.40 | 0.20 | 0.22 | 2.49 | 1.9e-09 | 1.30 (1.13:1.50) | 2.5e-04 | 1.77 (0.94) | 1.06 (0.91:1.22) | 0.465 |
| NESDA | 1133 | 271 | 0.32 | 0.11 | 0.14 | 3.83 | 8.3e-11 | 1.24 (1.09:1.43) | 0.002 | 1.36 (0.85) | 1.06 (0.87:1.28) | 0.587 |
| QIMR_3 | 186 | 55 | 0.44 | 0.18 | 0.22 | 3.66 | 7.0e-04 | 1.07 (0.79:1.46) | 0.670 | 0.13 (0.60) | 0.82 (0.52:1.25) | 0.355 |
| QIMR_3_M7 | 126 | 29 | 0.48 | 0.31 | 0.34 | 2.10 | 0.092 | 1.16 (0.75:1.80) | 0.494 | 0.66 (1.80) | 0.83 (0.49:1.40) | 0.496 |
| QIMR_6 | 121 | 107 | 0.38 | 0.23 | 0.29 | 2.05 | 0.016 | 0.90 (0.67:1.19) | 0.452 | 0.30 (0.78) | 0.87 (0.61:1.22) | 0.418 |
| QIMR_C | 180 | 46 | 0.40 | 0.33 | 0.33 | 1.36 | 0.387 | 0.83 (0.58:1.17) | 0.297 | 0.92 (1.70) | 0.89 (0.60:1.30) | 0.564 |
| RADIANT UK | 262 | 263 | 0.42 | 0.15 | 0.19 | 4.33 | 1.5e-11 | 1.61 (1.33:1.97) | 2.1e-06 | 5.46 (2.14) | 1.04 (0.83:1.30) | 0.761 |
| SHIP_0 | 352 | 1042 | 0.22 | 0.12 | 0.14 | 2.10 | 6.0e-06 | 1.31 (1.15:1.49) | 4.2e-05 | 1.95 (0.93) | 0.97 (0.86:1.10) | 0.606 |
| SHIP-TREND | 147 | 448 | 0.20 | 0.08 | 0.10 | 2.77 | 2.0e-04 | 1.34(1.09:1.64) | 0.005 | 2.14 (1.50) | 1.08 (0.88:1.35) | 0.460 |
|
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| Total | 3024 | 2741 | 0.35 | 0.14 | 0.17 | 2.63 | 3.5e-18 | 1.24(1.12:1.37) | 3.6e-05 | 1.18 (0.31) | 1.00 (0.93:1.07) | 0.894 |