Table 1.
Demographics of combined cases
| Group | Stage 0 | Stage I | Stage IIa | Stage IIb | Stage III | Stage IV |
|---|---|---|---|---|---|---|
| N (143) | 19 | 17 | 5 | 18 | 36 | 48 |
| Male:Female | 12:7 | 8:9 | 3:2 | 9:9 | 22:14 | 28:20 |
| Age at death (years) | 84.1±6.4 | 86.1±4.5 | 87.6±3.5 | 80.7±7.3 | 80.9±7.1 | 78.9±5.4* |
| PMD (hours) | 2.5±0.6 | 3.1±0.9 | 2.5±0. | 4.3±3.0* | 3.3±1.3 | 3.3±0.7 |
| ApoE (ε2: ε3: ε4 (%)) | 10.5:76.3:13.2 | 3.1:68.8:28.1 | 10:70:20 | 2.8:58.3:38.9 | 5.6:73.6:20.8 | 6.3:58.3:35.4 |
| LTS (Cing) | 0 | 0 | 0.2±0.45 | 0.47±0.51 | 1.82±0.83 | 3.19±0.73 |
| LTS (Temp) | 0 | 0 | 0 | 0.26±0.45 | 0.94±0.34 | 2.54±0.77 |
| Plaques | 3.8±4.2 | 12.5±2.1* | 9.3±4.2 | 13.2±2.2* | 6.5±5.1 | 10.6±4.3*@ |
| Tangles | 4.4±2.1 | 11.5±4.7* | 5.8±3.9 | 12.3±3.5* | 4.5±2.9* | 8.0±4.4*@ |
Numbers represent mean ± standard deviation
PMD: Postmortem delay. LTS (Cing): Lewy type density score (cingulate cortex)
LTS (Temp): Lewy type density score (temporal cortex)
*
significant difference (P< 0.05) between group and Stage 0 samples (ANOVA with post hoc test)
@
significant difference (P<0.05) between stage III and Stage IV samples (ANOVA with post hoc test)