Table 2.
Significant and Suggestive Multiethnic Meta-Analysis Results for Apnea–Hypopnea Index (Total), Apnea–Hypopnea Index–Non–Rapid Eye Movement, and Apnea–Hypopnea Index–Rapid Eye Movement
| Trait | SNP | Chr | Locus | Alleles | Sex Combined |
Women |
Men |
Sex Difference P Value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Effect | P Value | n | Effect | P Value | n | Effect | P Value | ||||||
| AHI-T | rs76321756 | 1 | C/T | 2,381 | 0.130 | 9.7 × 10−5 | 1,289 | −0.017 | 7.0 × 10−1 | 1,092 | 0.244 | 2.3 × 10−7 | 2.7 × 10−6 | |
| AHI-T | rs11897825 | 2 | AC011752.1; AC067959.1 | G/A | 15,364 | 0.026 | 2.2 × 10−2 | 7.650 | 0.080 | 3.3 × 10−7 | 7,714 | −0.014 | 3.6 × 10−1 | 2.8 × 10−3 |
| AHI-T | rs999944 | 2 | G/A | 19,733 | 0.072 | 9.7 × 10−7 | 10,113 | 0.063 | 2.0 × 10−3 | 9,620 | 0.077 | 2.6 × 10−4 | 5.5 × 10−3 | |
| AHI-T | rs35520189 | 2 | C/A | 19,733 | 0.052 | 6.1 × 10−7 | 10,113 | 0.064 | 5.8 × 10−6 | 9,620 | 0.042 | 5.3 × 10−3 | 5.9 × 10−1 | |
| AHI-T | rs72149316:AATAA | 2 | SCN3A | GATAA/AATAA | 1,679 | 0.428 | 6.0 × 10−7 | 919 | 0.326 | 3.7 × 10−3 | 764 | 0.606 | 5.9 × 10−7 | 2.3 × 10−3 |
| AHI-T | rs34526934 | 2 | HOXD-AS2;HOXD3;HOXD4;MIR10B | A/T | 19,505 | 0.060 | 1.1 × 10−6 | 9,998 | 0.024 | 1.7 × 10−1 | 9,507 | 0.087 | 3.6 × 10−7 | 1.8 × 10−3 |
| AHI-T | rs62189527 | 2 | HDAC4 | C/T | 12,665 | 0.174 | 4.6 × 10−5 | 7,384 | 0.067 | 2.3 × 10−1 | 5,281 | 0.320 | 7.4 × 10−7 | 9.7 × 10−4 |
| AHI-T | rs35001935:CGTGTGT | 3 | C3orf67; RP11-147N17.1 | CGTGT/CGTGTGT | 1,679 | 0.251 | 7.7 × 10−7 | 919 | 0.091 | 1.9 × 10−1 | 760 | 0.339 | 1.3 × 10−6 | 3.3 × 10−4 |
| AHI-T | chr3:166153534:D | 3 | A/AAC | 2.461 | 0.249 | 3.4 × 10−5 | 1,481 | 0.376 | 6.1 × 10−7 | 980 | 0.157 | 9.4 × 10−2 | 3.2 × 10−1 | |
| AHI-T | rs34188544 | 4 | G/A | 2,135 | 0.522 | 3.6 × 10−7 | 1,264 | 0.333 | 1.4 × 10−2 | 871 | 0.728 | 2.1 × 10−6 | 8.2 × 10−3 | |
| AHI-T | rs73352871 | 5 | C/A | 12,996 | 0.082 | 2.4 × 10−3 | 7,610 | −0.025 | 4.8 × 10−1 | 5,386 | 0.203 | 5.9 × 10−7 | 2.2 × 10−6 | |
| AHI-T | rs79987021 | 7 | T/C | 12,265 | 0.256 | 6.2 × 10−7 | 7,199 | 0.186 | 5.4 × 10−3 | 5,066 | 0.316 | 7.7 × 10−5 | 1.5 × 10−2 | |
| AHI-T | rs117004340 | 8 | DLC1 | T/A | 19,504 | 0.079 | 2.2 × 10−5 | 9,997 | −0.001 | 9.7 × 10−1 | 9,507 | 0.136 | 1.8 × 10−7 | 9.2 × 10−4 |
| AHI-T | rs3736021 | 8 | ENTPD4 | T/G | 19,732 | 0.065 | 7.2 × 10−7 | 10,112 | 0.057 | 1.1 × 10−3 | 9,620 | 0.071 | 3.4 × 10−4 | 1.1 × 10−1 |
| AHI-T | rs35857674 | 8 | SNTG1 | A/G | 19,732 | 0.024 | 2.2 × 10−2 | 10,112 | 0.070 | 7.9 × 10−7 | 9,620 | −0.016 | 2.8 × 10−1 | 5.2 × 10−3 |
| AHI-T | rs117169866 | 10 | G/A | 18,512 | 0.150 | 5.6 × 10−7 | 9,436 | 0.116 | 7.0 × 10−3 | 9,396 | 0.158 | 1.1 × 10−4 | 6.7 × 10−2 | |
| AHI-T | rs1387259 | 12 | RP11-370I10.2; ZNF641 | A/G | 19,733 | 0.052 | 2.3 × 10−6 | 10,113 | 0.031 | 4.1 × 10−2 | 9,620 | 0.078 | 3.7 × 10−7 | 2.3 × 10−2 |
| AHI-T | rs9600832 | 13 | NBEA | C/T | 19,733 | 0.064 | 1.2 × 10−5 | 10,113 | 0.012 | 5.4 × 10−1 | 9,620 | 0.104 | 5.6 × 10−7 | 7.8 × 10−5 |
| AHI-T | rs75900232 | 13 | G/A | 16,337 | 0.159 | 2.1 × 10−4 | 8,942 | −0.037 | 5.2 × 10−1 | 8,199 | 0.307 | 6.5 × 10−7 | 4.9 × 10−5 | |
| AHI-T | rs115432071 | 16 | C16orf62 | T/A | 12,996 | 0.197 | 8.5 × 10−6 | 7,610 | 0.055 | 3.4 × 10−1 | 5,386 | 0.346 | 3.0 × 10−7 | 1.6 × 10−4 |
| AHI-T | rs4787347 | 16 | HS3ST4 | G/A | 19,733 | 0.029 | 3.3 × 10−3 | 10,113 | 0.067 | 7.2 × 10−7 | 9,620 | 0.002 | 8.8 × 10−1 | 1.9 × 10−1 |
| AHI-T | rs112190082 | 17 | STX8 | G/T | 13,905 | 0.099 | 1.0 × 10−3 | 8,188 | 0.200 | 3.6 × 10−7 | 5,717 | 0.013 | 7.7 × 10−1 | 3.4 × 10−2 |
| AHI-T | rs113724004 | 17 | T/C | 19,505 | 0.069 | 5.9 × 10−5 | 9,998 | 0.020 | 4.0 × 10−1 | 9,507 | 0.123 | 8.0 × 10−7 | 3.9 × 10−4 | |
| AHI-T | rs142002225 | 20 | T/C | 19,733 | 0.055 | 2.8 × 10−4 | 10,113 | 0.108 | 3.2 × 10−7 | 9,620 | 0.022 | 3.1 × 10−1 | 3.4 × 10−1 | |
| AHI-N | rs146579140 | 2 | C/T | 6,737 | 0.206 | 8.8 × 10−8 | 2,412 | 0.092 | 1.6 × 10−1 | 4,212 | 0.237 | 5.2 × 10−7 | 1.3 × 10−2 | |
| AHI-N | rs10474877 | 5 | ANKRD33B | T/C | 6,737 | 0.039 | 1.1 × 10−1 | 2,412 | 0.203 | 2.1 × 10−7 | 4,212 | −0.015 | 6.2 × 10−1 | 3.7 × 10−2 |
| AHI-N | rs73686127 | 7 | A/T | 1,300 | 0.508 | 2.6 × 10−7 | 719 | 0.509 | 4.7 × 10−5 | 367 | 0.464 | 4.6 × 10−3 | 2.2 × 10−1 | |
| AHI-N | rs10968431 | 9 | LINGO2 | G/A | 1,300 | 0.239 | 5.3 × 10−4 | 719 | −0.030 | 7.5 × 10−1 | 581 | 0.474 | 9.7 × 10−7 | 1.3 × 10−5 |
| AHI-N | rs79697311 | 11 | C/A | 6,029 | 0.215 | 5.2 × 10−3 | 1,295 | 0.719 | 6.9 × 10−7 | 3,885 | 0.176 | 6.9 × 10−2 | 4.2 × 10−1 | |
| AHI-N | rs34174435 | 11 | OR5AN1 | GA/G | 5,304 | 0.101 | 6.4 × 10−7 | 1,673 | 0.105 | 4.4 × 10−3 | 3,631 | 0.086 | 3.3 × 10−4 | 1.1 × 10−1 |
| AHI-N | rs75482679 | 11 | CNTN5 | T/C | 6,737 | 0.128 | 1.0 × 10−5 | 2,412 | −0.019 | 6.9 × 10−1 | 4,325 | 0.176 | 8.7 × 10−7 | 1.3 × 10−4 |
| AHI-N | rs72986876 | 11 | PDGFD | A/T | 6,511 | 0.223 | 7.8 × 10−7 | 2,299 | 0.194 | 1.3 × 10−2 | 4,212 | 0.217 | 7.9 × 10−5 | 4.4 × 10−1 |
| AHI-N | rs116696666 | 16 | A/T | 1,300 | 0.290 | 1.6 × 10−3 | 719 | 0.608 | 5.9 × 10−7 | 581 | 0.136 | 3.1 × 10−1 | 2.5 × 10−1 | |
| AHI-N | rs12936587 | 17 | RAI1 | G/A | 6,737 | 0.083 | 6.9 × 10−7 | 2,412 | −0.008 | 7.7 × 10−1 | 4,325 | 0.116 | 1.7 × 10−8 | 2.6 × 10−5 |
| AHI-R | chr1:74135031 | 1 | RP4-788P17.1 | A/T | 1,546 | 0.310 | 9.8 × 10−7 | 858 | 0.208 | 1.0 × 10−2 | 688 | 0.403 | 5.2 × 10−5 | 1.2 × 10−1 |
| AHI-R | rs72956768 | 4 | TMEM154 | G/T | 1,290 | 0.254 | 6.4 × 10−4 | 714 | 0.020 | 8.3 × 10−1 | 576 | 0.563 | 5.2 × 10−7 | 1.5 × 10−4 |
| AHI-R | rs35077018 | 7 | HUS1; PKD1L1 | G/GCTAGTGCGTGCATGAACTAGTTGGTCTGCAAGTACAAGATGTATAAATATACAGGGGAAAAAACATC | 1,290 | 0.198 | 5.5 × 10−4 | 714 | 0.357 | 8.2 × 10−7 | 576 | 0.049 | 5.9 × 10−1 | 3.4 × 10−2 |
| AHI-R | rs9297743 | 8 | RP11-89K10.1 | G/A | 6,700 | 0.127 | 5.5 × 10−4 | 2,400 | −0.037 | 5.1 × 10−1 | 4,300 | 0.241 | 9.2 × 10−7 | 2.6 × 10−3 |
| AHI-R | rs79697311 | 11 | C/A | 5,998 | 0.173 | 1.8 × 10−2 | 1,289 | 0.692 | 4.4 × 10−7 | 3,867 | 0.068 | 4.7 × 10−1 | 4.6 × 10−2 | |
| AHI-R | rs201360344 | 12 | C12orf55 | G/GA | 924 | 0.478 | 5.5 × 10−7 | 498 | 0.516 | 3.2 × 10−5 | 426 | 0.329 | 3.1 × 10−2 | 4.1 × 10−1 |
| AHI-R | rs41408454 | 15 | G/A | 1,290 | 0.287 | 1.1 × 10−3 | 714 | 0.523 | 8.8 × 10−7 | 576 | 0.019 | 8.9 × 10−1 | 1.2 × 10−2 | |
Definition of abbreviations: AHI = apnea–hypopnea index; AHI-N = non–rapid eye movement sleep–specific AHI; AHI-R = rapid eye movement sleep-specific AHI; AHI-T = AHI-total; Chr = chromosome.
SNPs with significant (P < 5.0 × 10−8) and suggestive (P < 1.0 × 10−6) P values. SNPs that were present in only one ethnic group were excluded. Alleles: effect allele/noneffect allele.