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Absence of CotE slows progression of Clostridium difficile infection. Groups of hamsters (n = 6) were administered clindamycin and, 16 h later, dosed by intragastric gavage with spores (102) of C. difficile 630 (wild-type, cotE+), cotE–, and cotEC–. A, Kaplan–Meier survival. B, Time from initial symptoms (wet tail and/or presence of fecal toxins) to clinical endpoint (virulent phase) are shown. Note that 1 hamster from each mutant group was not colonized and did not show symptoms.
