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. 2018 Mar 6;5:17. doi: 10.3389/fcvm.2018.00017

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Copyright © 2018 Gopal, Almutairi, Al Batran, Eaton, Gandhi and Ussher

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered myocardial energy metabolism and normal ex vivo cardiac function in Pdha1^{Cardiac−/−} mice. (A) Glucose oxidation rates, (B) palmitate oxidation rates, (C) cardiac output, (D) left ventricular (LV) work, (E) aortic flow, (F) coronary flow, (G) aortic systolic pressure, and (H) aortic diastolic pressure during isolated aerobic working heart perfusions from Pdha1^{Cardiac−/−} and their αMHC-MerCreMer control littermates (n = 4, 5). Values represent means ± SEM. Differences were determined using an unpaired, two-tailed Student’s t-test. *P < 0.05.