Table 2.
m6A regulators are associated with cancer
| m6A regulator | Cancer type | Details | References (Pubmed ID) |
|---|---|---|---|
| METTL3 | Lung cancer | METTL3 promotes growth, survival, and invasion of human lung cancer cells by increasing translation of mRNAs | 27117702 |
| METTL14 | Hepatocellular carcinoma | By interacting with DGCR8, METTL14 increases primary miRNA 126 and decreases mature miRNA 126 in an m6A-dependent manner, while mature miRNA 126 inhibits the repressing effect of METTL14 in tumor metastasis | 27774652 |
| FTO, METTL3 | Osteosarcoma, malignant melanoma | m6A RNA serves as a beacon for the selective, rapid recruitment of Pol κ to damage sites to facilitate repair and cell survival | 28297716 |
| FTO, METTL3, or METTL14 | Glioblastoma | m6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells by regulating mRNA m6A enrichment and expression. FTO inhibitor MA2 suppresses glioblastoma progression at in vitro and in vivo studies | 28297667 |
| FTO | Acute myeloid leukemia | High expression of FTO promotes leukemogenesis in subtypes of AML. By lowering the m6A level, FTO downregulates, key targets ASB2 and RARA expression, and inhibits all-trans-retinoic acid-induced leukemia cell differentiation | 28017614 |
| ALKBH5 | Glioblastoma | High expression of ALKBH5 promotes self-renewal and tumorigenesis of glioblastoma stem-like cells through regulation of FOXM1. The lncRNA antisense to FOXM1 links ALKBH5 to FOXM1 nascent RNA, leading to demethylation and elevated expression of FOXM1 | 28344040 |
| ALKBH5 | Breast cancer | Hypoxia-inducible factors promote pluripotency factor expression of breast cancer stem cell by inducing ZFP217-dependent inhibition of m6A methylation under hypoxic tumor microenvironment | 27590511 |
| ALKBH5 | Breast cancer | Hypoxia-inducible factors-dependent ALKBH5 expression mediates enrichment of BCSCs by decreasing NANOG mRNA methylation and increasing its mRNA levels | 27001847 |
| YTHDF2 | Hepatocellular carcinoma | miR 145 modulates m6A levels by targeting the 3ʹ UTR of YTHDF2 mRNA in HCC cells | 28104805 |
m6A N6-methyladenosine, METTL3 metyltransferase-like 3, METTL14 metyltransferase-like 14, DGCR8, DGCR8, microprocessor complex subunit, miRNA microRNA, FTO fat mass and obesity-associated, Pol κ DNA polymerase κ, MA2 the ethyl ester derivative of meclofenamic acid, AML acute myeloid leukemia, ASB2 ankyrin repeat and SOCS box protein 2, RARA retinoic acid receptor-a, ALKBH5 AlkB homologue 5, lncRNA long-non-coding RNA, FOXM1 fork head box M1, ZFP217 zinc-finger protein 217, BCSCs breast cancer stem cells, NANOG homeobox transcription factor Nanog, YTHDF2 YTH m6A-binding protein 2