Figure 2.
SUS in aged APP23 mice does not augment microbleeds and cerebral amyloid angiopathy (CAA). (A) Perl's Prussian blue staining detecting hemosiderin deposits reveals significant iron deposition in brains of aged APP23 mice, with no difference in numbers between sham- and SUS-treated mice. Blue spots label iron deposits from previous microbleeds. (B) Hematoxylin and eosin (H&E) staining reveals small acute cerebral microbleeds known as petechiae only in one sham- and one SUS-treated mouse in the sections analyzed. (C) Prominent amyloid-laden vessels (pathology known as CAA) are found in aged APP23 mice, with their length not differing between sham- and SUS-treated mice as determined with methoxy-XO4. Scale bars: 100 μm, data shown as mean ± SEM. White arrows indicate microbleeds.