Table IV.
Clinical trials testing cancer vaccines for pancreatic cancer.
| Antigen & Drug | ClinicalTrials.gov Identifier | Phase | No. of Patients | Status |
|---|---|---|---|---|
| MUC1 Vaccine (Cvac vaccine) | NCT02310971* | II | 0 | Withdrawn |
| Falimarev (MUC1 PANVAC-F vaccine) + Inalimarev (MUC1 PANVAC-V vaccine) + Sargramostim (GM-CSF vaccine) | NCT00669734* | I | 18 | Ongoing |
| Telomerase vaccine (GV1001) + gemcitabine + Sargramostim + tadalafil + Radiation Therapy | NCT01342224* | I | 11 | Active |
| Telomerase vaccine (GV1001) + Sargramostim + capecitabine + gemcitabine | NCT00425360* | III | 1110 | Completed |
| CEA vaccine (ALVAC + vaccinia) + aldesleukin (IL-2) + Sargramostim | NCT00003125* | II | 24 | Completed |
| CEA vaccine (AVX701) | NCT00529984* | I & II | 28 | Completed |
| Recombinant fowlpox-CEA(6D)/TRICOM vaccine + GM-CSF vaccine + Sargramostim | NCT00028496* | I | 48 | Completed |
| Recombinant fowlpox-CEA(6D)/TRICOM vaccine + denileukin diftitox + therapeutic autologous dendritic cells | NCT00128622* | I | 24 | Completed |
| CEA vaccine (TRICOM-CEA(6D)) | NCT00027534* | I | 14 | Completed |
| CEA RNA-pulsed DC cancer vaccine | NCT00004604* | I | 24 | Completed |
| CEA vaccine (carcinoembryonic antigen peptide 1-6D) + incomplete Freund’s adjuvant + sargramostim | NCT00012246* | II | 7 | Terminated |
| K-ras vaccine (TG01) + GM-CSF + Gemcitabine | NCT02261714* | I & II | 32 | Active |
| Aldesleukin + ras peptide cancer vaccine + sargramostim + DetoxPC | NCT00019331* | II | 11 | Completed |
| HLA-A*02:01 -restricted VEGFR1-derived peptide vaccination | NCT00683085* | I & II | 2 | Terminated |
| VEGFR-2 DNA vaccine VXM01 | NCT01486329* | I | 72 | Completed |
| Mesothelin vaccine (CRS-207) + GVAX vaccine + gemcitabine + capecitabine + 5-FU + irinotecan or erlotinib + cyclophosphamide |
NCT02004262 [Ref no. 87, 88] |
II | 303 | Completed |
| GVAX Pancreas + Mesothelin vaccine (CRS-207) + Cyclophosphamide |
NCT01417000 [Ref. no. 88] |
II | 93 | Ongoing |
| Mesothelin vaccine (CRS-207) | NCT00585845* | I | 17 | Terminated |
| Cancer stem cell vaccine | NCT02074046* | I & II | 40 | Completed |
Data obtained from https://clinicaltrials.gov/