Table 1.
MRL-436 inhibits RNAP, including Rif-resistant RNAPs
| enzyme | IC50 (μM) | |
|---|---|---|
|
| ||
| MRL-436 | Rif | |
| RNAP | 2 | 0.03 |
| [D516V]β-RNAP | 4 | 70 |
| [H526D]β-RNAP | 3 | >100 |
| [S531L]β-RNAP | 4 | 80 |
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