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. Author manuscript; available in PMC: 2018 Dec 7.
Published in final edited form as: Mol Cell. 2017 Nov 16;68(5):872–884.e6. doi: 10.1016/j.molcel.2017.10.025

Figure 5. Example of PRC2 bound genes upregulated in Eed−/− and EloAK754R.

Figure 5

Genome browser profiles of 7 representative, expressed genes upregulated in K754R edited and Eed −/− mES cells that show PRC2 enrichment (red EZH2 ChIP-seq track). Olig2 depicts a silent gene that is only upregulated in Eed−/− mES cells. RNA-seq values represent average RPKM (bin size=50bp, n=2). Bru-seq tracks (green) represent nascent transcription signal from a 10min 5-bromouridine pulse experiment. Only the intronic RPKM signals were used for differential gene expression comparison for Bru-seq.