Table 1.
Peroxisomal proteins and their relevance with pathological aspects
| Gene | Function | Diseases | References |
|---|---|---|---|
| PEX1 | Peroxisome fusion and/or peroxisomal matrix protein import | IRD, NALD, ZSD, HS | Reuber et al., 1997; Smith et al., 2016; Tamura et al., 2001; Yik et al., 2009 |
| PEX2 | Peroxisomal matrix protein import | ZS, Mild ZSD, IRD | Shimozawa et al., 1999a |
| PEX3 | The assembly and maintenance of the peroxisomal membrane | ZS, Mild IRD | Muntau et al., 2000 |
| PEX5 | Peroxisomal matrix proteins carrying PTS1 | NALD, ZSD, RCDP5 | Barøy et al., 2015; Shimozawa et al., 1999c |
| PEX6 | Peroxisome fusion and/or peroxisomal matrix protein import | NALD, ZSD, HS | Smith et al., 2016; Yik et al., 2009; Zhang et al., 1999 |
| PEX7 | Peroxisomal matrix proteins carrying PTS2 | RCDP1, Mild RD | Braverman et al., 1997; van den Brink et al., 2003 |
| PEX10 | Peroxisomal matrix protein import | NALD, ZSD | Warren et al., 1998; Yik et al., 2009 |
| PEX11β | Peroxisome division | Mild ZSD | Ebberink et al., 2012 |
| PEX12 | Peroxisomal matrix protein import | IRD, NALD, ZSD | Chang et al., 1997; Yik et al., 2009 |
| PEX13 | Peroxisomal matrix protein import | NALD, ZSD | Al-Dirbashi et al., 2009; Liu et al., 1999; Shimozawa et al., 1999b |
| PEX14 | The initial docking site for PTS1 and PTS2 receptors of matrix proteins/an essential component of peroxisomal import machinery | ZS | Huybrechts et al., 2008 |
| PEX16 | Peroxisome division or peroxisomal membrane biogenesis | ZSD | South and Gould, 1999 |
| PEX19 | The import and/or membrane assembly of numerous peroxisomal membrane proteins. | ZS | Matsuzono et al., 1999 |
| PEX26 | Receptor export, membrane receptors for Pex1 and Pex6 | ZSD. NALD, IRD | Matsumoto et al., 2003; Yik et al., 2009 |
| ACBD5 (Atg37) | Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy | Retinal dystrophy, WMD | Ferdinandusse et al., 2017 |
ATM, Ataxia-telangiectasia mutated; HS, Heimler syndrome; IRD, Infantile refsum disease; NALD, Neonatal adrenoleukodystrophy; RCDP, Rhizomelic chondrodysplasia punctate; WMD, White matter dementia; ZS, Zellweger syndrome; ZSD, Zellweger spectrum disorders