Table 3.
Mandibular mean dosimetric values for 584 patients without mandibular osteoradionecrosis and 41 patients (40 IMRT patients and 1 IMPT patient) with mandibular osteoradionecrosis.
| No Mandibular Osteoradionecrosis 537 patients | With Mandibular Osteoradionecrosis 41 patients | P Value | |
|---|---|---|---|
| Min dose, cGy | 661.25 | 897.73 | <0.001 |
| Max dose, cGy | 7151.20 | 7411.19 | <0.001 |
| Mean dose, cGy | 3932.26 | 4676.50 | <0.001 |
| V5, % | 97.54 | 98.84 | 0.360 |
| V10, % | 95.95 | 98.06 | 0.740 |
| V15, % | 89.33 | 95.75 | <0.001 |
| V20, % | 84.20 | 92.75 | <0.001 |
| V25, % | 77.66 | 87.27 | <0.001 |
| V30, % | 69.00 | 78.40 | <0.001 |
| V35, % | 58.95 | 69.74 | <0.001 |
| V40, % | 48.90 | 61.98 | <0.001 |
| V45, % | 39.70 | 53.74 | <0.001 |
| V50, % | 31.70 | 45.96 | <0.001 |
| V55, % | 24.24 | 37.91 | <0.001 |
| V60, % | 16.72 | 29.97 | <0.001 |
| V65, % | 9.43 | 21.54 | <0.001 |
| V70, % | 3.63 | 10.66 | <0.001 |
Abbreviations: IMRT, intensity-modulated (photon) radiation therapy; IMPT, intensity-modulated proton therapy; Vx, percentage volume of the mandible that received ≥x dose of radiation.