Figure 7. Comparison between developing mouse and human retina.
A. Open-Ended Dynamic time warping analysis for comparison of embryonic (E) 11–Postnatal (P) 28 retinae with human D52–D136 retinae. There were 2661 differentially expressed genes in humans that had 1:1 mapping with mouse. Expression data of these genes were subjected to Open-Ended Dynamic Time Warping analysis and the results are plotted as a heatmap. B. Spearman correlation of 109 retinal genes reveal that early human retinae are similar to embryonic mouse retinae, but at later developmental times, the mouse and human retinae segregate. C. Pearson correlation of human and mouse genes. Approximately 38% of the genes were highly correlated between mouse and human (Pearson correlation coefficient ≥ 0.7), approximately 57% of the genes were semi/non-correlated (Pearson correlation coefficient > −0.7 and < 0.7), and approximately 5% of the genes were anti-correlated (Pearson correlation coefficient ≤ −0.7). Enriched GO terms for the correlated and semi/non-correlated are presented as well as several significantly expressed non-correlated genes. Heatmaps were generated using Z-scores of expressed genes and AP clustering.