Table 2.
Randomized, double-blind, placebo-controlled trials of hormone therapy in older women without dementia: dementia outcomes in the Women’s Health Initiative Memory Studya
| Reference | Age, range |
Type menopauseb |
Number | Duration | Number of events |
Hazard ratio (95% confidence interval) |
Probability |
|---|---|---|---|---|---|---|---|
| Shumaker et al. (2003) | 65–79 y | Surgical | 4532 | 4.1 years | 61 | 2.1 (1.2 – 3.5) | 0.01 |
| Shumaker et al. (2004) | 65–79 y | Natural | 2947 | 5.2 years | 47 | 1.5 (0.8 – 2.7) | 0.18 |
a
Active treatment was with conjugated equine estrogens (0.625 mg/d) plus medroxyprogesterone acetate (2.5 mg/d) in a continuous combined oral formulation (Shumaker et al., 2003) or conjugated equine estrogens alone (Shumaker et al., 2004).
b
Surgical menopause based on hysterectomy status; in the parent Women’s Health Initiative, 41% of women with hysterectomy reported bilateral oophorectomy (Stefanick et al., 2003).