. 2018 Jan 17;8:981. doi: 10.1038/s41598-017-18670-7

Table 3.

Results of genetic models for VDR ApaI, VDR BsmI, VDR TaqI, VDR Cdx2 and VDR FokI polymorphisms and osteoporosis susceptibility in postmenopausal women.

Comparison	N	Test of association			Model	Test of heterogeneity		Begg’s test	Egger’s test
Comparison	N	OR	95% CI	P value	Model	P value	I² (%)	P value	P value
VDR *Apa* I
Overall	18
a vs. A		0.95	0.793–1.13	0.53	R	<0.001	69.2	0.649	0.575
aa vs. AA		0.84	0.61–1.15	0.271	R	<0.001	60.4	0.325	0.405
Aa vs. AA		0.86	0.73–1.01	0.063	F	0.091	32.4	0.13	0.075
Aa/aa vs. AA		0.84	0.73–0.98	0.022	F	0.020	45.3	0.058	0.076
aa vs. AA/Aa		0.93	0.70–1.23	0.609	R	<0.001	66.6	0.363	0.484
Caucasian	15
a vs. A		0.94	0.80–1.12	0.505	R	0.001	61.6
aa vs. AA		0.84	0.58–1.20	0.33	R	0.001	60.5
Aa vs. AA		0.84	0.70–0.99	0.042	F	0.046	41.7
Aa/aa vs. AA		0.85	0.72–1.00	0.047	F	0.017	48.8
aa vs. AA/Aa		0.93	0.69–1.24	0.609	R	0.002	58.5
Asian	3
a vs. A		0.99	0.48–2.06	0.98	R	<0.001	69.2
aa vs. AA		0.86	0.38–1.96	0.727	R	0.033	70.8
Aa vs. AA		1.04	0.65–1.67	0.879	F	0.803	0
Aa/aa vs. AA		0.81	0.57–1.15	0.238	F	0.163	44.8
aa vs. AA/Aa		0.96	0.36–2.60	0.942	R	<0.001	88.1
VDR *Bsm* I
Overall	36
B vs. b		1.21	1.00–1.46	0.052	R	<0.001	83	0.215	0.198
BB vs. bb		1.4	0.97–2.01	0.072	R	<0.001	79.4	0.358	0.194
Bb vs. bb		1.27	0.99–1.64	0.06	R	<0.001	73.4	0.505	0.409
BB/Bb vs. bb		1.32	1.01–1.72	0.044	R	<0.001	79.5	0.522	0.314
BB vs. Bb/bb		1.21	0.93–1.57	0.159	R	<0.001	71.9	0.202	0.107
Caucasian	29
B vs. b		1.09	0.90–1.33	0.385	R	<0.001	82.4
BB vs. b		1.18	0.81–1.71	0.396	R	<0.001	78.3
Bb vs. bb		1.19	0.89–1.59	0.246	R	<0.001	76.8
BB/Bb vs. bb		1.19	0.88–1.59	0.262	R	<0.001	80.6
BB vs. Bb/bb		1.08	0.81–1.37	0.682	R	<0.001	68.9
Asian	7
B vs. b		2.02	1.30–3.12	0.002	R	0.005	68.1
BB vs. bb		4.16	2.20–7.88	<0.001	R	0.207	32.1
Bb vs. bb		1.73	1.24–2.42	0.001	R	0.455	0
BB/Bb vs. bb		2.14	1.34–3.42	0.001	R	0.064	49.6
BB vs. Bb/bb		2.98	1.76–5.05	<0.001	R	0.267	23.1
VDR *Taq* I
Overall	17
t vs. T		1.03	0.83–1.28	0.782	R	<0.001	75.6	0.149	0.053
tt vs. TT		1.03	0.68–1.56	0.873	R	<0.001	69.2	0.053	0.023
Tt vs. TT		1.09	0.81–1.47	0.573	R	<0.001	66.7	0.484	0.363
Tt/tt vs. TT		1.07	0.79–1.46	0.66	R	<0.001	73	0.232	0.155
tt vs. Tt/TT		1.03	0.76–1.39	0.848	R	0.003	55.9	0.07	0.07
Caucasian	16
t vs. T		0.99	0.79–1.24	0.944	R	<0.001	74.4
tt vs. TT		0.97	0.63–1.48	0.872	R	<0.001	67.9
Tt vs. TT		1.05	0.77–1.44	0.747	R	<0.001	67.5
Tt/tt vs. T		1.02	0.74–1.41	0.89	R	<0.001	72.7
tt vs. Tt/TT		0.98	0.71–1.34	0.888	R	0.005	54.7
VDR *Cdx* 2
Caucasian	3
A vs. G		0.67	0.23–1.96	0.466	R	<0.001	90.9	1	0.322
AA vs. GG		0.45	0.05–3.81	0.462	R	0.009	78.7	1	0.74
GA vs. GG		0.8	0.29–2.22	0.665	R	0.011	77.8	0.296	0.115
AA/GA vs. GG		0.65	0.20–2.12	0.479	R	0.002	84.1	0.296	0.01
AA vs. GG/GA		0.56	0.14–2.20	0.405	R	0.049	66.8	1	0.866
VDR *Fok* I
Overall	15
f vs. F		1.1	0.91–1.33	0.301	R	<0.001	63.3	0.621	0.615
ff vs. FF		1.26	0.84–1.89	0.262	R	0.001	61.4	1	0.451
Ff vs. FF		1.14	0.97–1.33	0.113	F	0.186	24.3	0.621	0.402
Ff/ff vs. FF		1.19	1.03–1.38	0.021	F	0.029	45.3	0.373	0.593
ff vs. Ff/FF		1.23	0.87–1.75	0.243	R	0.004	56.2	1	0.593
Caucasian	13
f vs. F		1.02	0.85–1.23	0.844	R	0.006	57
ff vs. FF		1.07	0.71–1.63	0.741	R	0.006	56.4
Ff vs. FF		1.1	0.93–1.30	0.26	F	0.152	29.1
Ff/ff vs. FF		1.12	0.96–1.31	0.146	F	0.06	41.2
ff vs. Ff/FF		1.08	0.75–1.56	0.684	R	0.016	51.7
Asian	2
f vs. F		1.88	1.38–2.58	<0.001	R	0.844	0
ff vs. FF		3.05	1.67–5.60	<0.001	R	0.408	0
Ff vs. FF		1.53	0.92–2.54	0.101	F	0.971	0
Ff/ff vs. FF		1.95	1.23–3.08	0.004	F	0.938	0
ff vs. Ff/FF		2.47	1.43–4.27	0.001	R	0.395	0

R: random effect model.

F: fixed effect model.