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. 2018 Jan 17;8:981. doi: 10.1038/s41598-017-18670-7

Table 1.

General characteristics of studies assciated with postmenopausal osteoporosis risk.

Author Year Ethnicity Sample Size VDR ApaI
Case Control
Case Control A a AA Aa aa A a AA Aa aa
Sassi et al. 2015 Caucasian 141 231 103 179 25 53 63 167 295 26 115 90
Castelán-Martínez et al. 2015 Caucasian 387 147 332 442 86 160 141 127 167 26 75 46
González-Mercado et al. 2013 Caucasian 88 87 99 77 26 47 15 99 75 29 41 17
Marozik et al. 2013 Caucasian 54 77 70 38 23 24 7 62 92 14 34 29
Yoldemir et al. 2011 Caucasian 130 130 128 132 34 60 36 135 125 31 73 26
Luan et al. 2011 Asian 77 227 93 61 42 9 26 221 233 102 17 108
Tanriover et al. 2010 Caucasian 50 50 53 47 15 23 12 57 43 22 13 15
Seremak-Mrozikiewicz et al. 2009 Caucasian 163 63 152 174 35 82 46 56 70 12 32 19
Uysal et al. 2008 Caucasian 100 146 120 80 35 50 15 171 121 46 79 21
Chen et al. 2007 Asian 82 113 24 140 4 16 62 65 161 12 41 60
Mitra et al. 2006 Asian 119 97 144 94 50 44 25 101 93 34 33 30
Duman et al. 2004 Caucasian 75 66 82 68 13 56 6 75 57 15 45 6
Douroudis et al. 2003 Caucasian 35 44 36 34 11 14 10 60 28 17 26 1
Zajícková et al. 2002 Caucasian 65 33 79 51 23 33 9 37 29 10 17 6
Langdahl et al. 2000 Caucasian 78 74 88 68 22 44 12 82 66 25 32 17
Gennari et al. 1998 Caucasian 160 144 217 103 68 81 11 152 136 34 84 26
Vandevyver et al. 1997 Caucasian 87 699 85 89 20 45 22 769 629 197 375 127
Riggs et al. 1995 Caucasian 40 128 43 37 12 19 9 135 121 38 59 31
Author Year Ethnicity Sample Size VDR Bsm I
Case Control
Case Control B b BB Bb bb B b BB Bb bb
D. Boroń et al. 2015 Caucasian 278 292 323 233 101 121 56 369 215 128 113 51
Marozik et al. 2013 Caucasian 54 77 55 53 12 31 11 48 106 11 26 40
Pouresmaeili et al. 2013 Caucasian 64 82 61 67 14 33 17 59 105 13 33 36
González-Mercado et al. 2013 Caucasian 88 88 40 136 6 28 54 46 130 4 38 46
Efesoy et al. 2011 Caucasian 40 30 33 47 5 23 12 25 35 5 15 10
Yoldemir et al. 2011 Caucasian 130 130 117 143 22 73 35 109 151 22 65 43
Tanriover et al. 2010 Caucasian 50 50 49 51 15 19 16 45 55 19 7 24
Mansour et al. 2010 Caucasian 50 20 69 31 27 15 8 4 36 1 2 17
Musumeci et al. 2009 Caucasian 100 200 114 86 30 54 16 133 267 15 103 82
Mencej-Bedrac et al. 2009 Caucasian 240 228 164 316 27 110 103 180 276 40 100 88
Seremak-Mrozikiewicz et al. 2009 Caucasian 163 63 120 206 27 66 70 47 79 10 27 26
Pérez et al. 2008 Caucasian 64 68 69 59 17 35 12 72 64 20 32 16
Uysal et al. 2008 Caucasian 100 146 84 116 18 48 34 126 166 24 78 44
Mitra et al. 2006 Asian 119 97 148 90 51 46 22 76 118 19 38 40
Duman et al. 2004 Caucasian 75 66 90 60 18 54 3 76 56 17 42 7
Zhu et al. 2004 Asian 40 158 38 42 6 26 8 119 197 7 105 46
Douroudis et al. 2003 Caucasian 35 44 18 52 3 12 20 49 39 10 29 5
Chen et al. 2003 Asian 40 21 7 73 0 7 33 3 39 0 3 18
Lisker et al. 2003 Caucasian 66 57 47 85 15 17 34 64 50 13 38 6
Borjas-Fajardo et al. 2003 Caucasian 54 55 76 32 28 20 6 58 52 11 36 8
Zajícková et al. 2002 Caucasian 65 33 66 64 21 24 20 33 33 10 13 10
Pollak et al. 2001 Asian 75 143 64 86 13 38 24 99 187 16 67 60
Aerssens et al. 2000 Caucasian 135 239 112 158 26 60 49 229 249 52 125 62
Langdahl et al. 2000 Caucasian 80 80 84 76 23 38 19 84 76 25 34 21
Garrofé et al. 2000 Caucasian 75 51 67 83 9 49 17 42 60 10 22 19
Poggi et al. 1999 Caucasian 50 225 47 53 6 35 9 47 53 63 95 67
Go´mez et al. 1999 Caucasian 37 122 34 40 7 20 10 91 153 20 51 51
Gennari et al. 1998 Caucasian 155 136 172 138 40 92 23 98 174 11 76 49
Zhang et al. 1998 Asian 17 162 3 31 0 3 14 14 310 0 14 148
Vandevyver et al. 1997 Caucasian 86 698 74 98 12 50 24 622 774 127 368 203
Houstan et al. 1996 Caucasian 44 44 35 53 8 19 17 37 51 9 19 16
Berg et al. 1996 Caucasian 19 30 16 22 4 8 7 27 33 8 11 11
Yanagi et al. 1996 Asian 46 66 36 56 12 12 22 11 121 2 7 57
Riggs et al. 1995 Caucasian 40 129 38 42 9 20 11 101 157 20 61 48
Lim et al. 1995 Asian 72 70 13 131 2 9 61 11 129 1 9 60
Melhus et al. 1994 Caucasian 70 76 57 83 14 29 27 103 49 34 35 7
Author Year Ethnicity Sample Size VDR Taq I
Case Control
Case Control T t TT Tt tt T t TT Tt tt
Ziablitsev et al. 2015 Caucasian 44 30 58 30 20 18 6 20 40 4 12 14
Sassi et al. 2015 Caucasian 141 231 173 109 58 57 26 301 161 103 95 33
González-Mercado et al. 2013 Caucasian 88 88 136 40 54 28 6 128 48 46 36 6
Marozik et al. 2013 Caucasian 54 77 60 48 17 26 11 102 52 39 24 14
Yoldemir et al. 2011 Caucasian 130 130 161 99 51 59 20 157 103 49 59 22
Tanriover et al. 2010 Caucasian 50 50 59 41 15 29 6 67 33 25 17 8
Seremak-Mrozikiewicz et al. 2009 Caucasian 163 63 215 111 78 59 26 73 53 22 29 12
Uysal et al. 2008 Caucasian 100 146 126 74 40 46 14 183 109 54 75 17
Mitra et al. 2006 Asian 119 97 110 128 34 42 43 119 75 44 31 22
Duman et al. 2004 Caucasian 75 66 88 62 23 42 10 74 58 23 28 15
Douroudis et al. 2003 Caucasian 35 44 51 19 19 13 3 43 45 8 27 9
Zajícková et al. 2002 Caucasian 65 33 77 53 23 31 11 36 30 11 14 8
Langdahl et al. 2000 Caucasian 78 75 87 69 23 41 14 90 60 28 34 13
Masi et al. 1998 Caucasian 90 111 62 118 13 36 41 82 140 9 64 38
Gennari et al. 1998 Caucasian 160 144 153 167 33 87 40 195 93 62 71 11
Vandevyver et al. 1997 Caucasian 46 284 52 40 11 30 5 341 227 91 159 34
Riggs et al. 1995 Caucasian 41 130 45 37 11 23 7 163 97 53 57 20
Author Year Ethnicity Sample Size VDR Cdx 2
Case Control
Case Control G A GG GA AA G A GG GA AA
Marozik et al. 2013 Caucasian 54 77 95 13 41 13 0 130 24 53 24 0
Ziablitsev et al. 2015 Caucasian 44 30 52 36 16 20 8 16 44 2 12 16
Mencej-Bedrac et al. 2009 Caucasian 239 228 385 93 155 75 9 392 64 172 48 8
Author Year Ethnicity Sample Size VDR Fok I
Case Control
Case Control F f FF Ff ff F f FF Ff ff
Langdahl et al. 2000 Caucasian 79 80 97 61 28 41 10 99 61 34 31 15
Tanriover et al. 2010 Caucasian 50 50 76 24 27 22 1 76 24 29 18 3
Zajícková et al. 2002 Caucasian 65 33 80 50 26 28 11 35 31 7 21 5
Yasovanthi et al. 2011 Caucasian 247 254 327 167 104 119 24 368 140 122 124 8
Gennari et al. 1999 Caucasian 164 119 193 135 60 73 31 161 77 53 55 11
Choi et al. 2000 Asian 48 65 47 49 12 23 13 85 45 26 33 6
Lucotte G et al. 1999 Caucasian 124 105 159 89 45 69 10 132 78 40 52 13
Lisker et al. 2003 Caucasian 65 57 83 47 27 29 9 69 45 20 29 8
Mitra et al. 2006 Asian 119 97 118 120 38 42 39 125 69 46 33 18
Mansour et al. 2010 Caucasian 50 20 77 23 34 9 7 40 0 20 0 0
Mencej-Bedrac et al. 2009 Caucasian 240 228 284 196 88 108 44 307 149 105 97 26
Pérez et al. 2008 Caucasian 64 68 76 52 22 32 10 80 56 22 36 10
Yoldemir et al. 2011 Caucasian 130 130 187 73 66 55 9 179 81 62 55 13
Mohammadi et al. 2015 Caucasian 139 31 163 115 80 3 56 25 37 11 3 17
González-Mercado et al. 2013 Caucasian 88 88 98 78 25 48 15 93 83 24 45 19