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. 2018 Jan 1;29(1):42–50. doi: 10.1089/hum.2017.049

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© Wei Zhang et al. 2018; Published by Mary Ann Liebert, Inc.

This article is available under the Creative Commons License CC-BY-NC (http://creativecommons.org/licenses/by-nc/4.0). This license permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Permission only needs to be obtained for commercial use and can be done via RightsLink.

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Figure 3. — In vivo physiological rescue potential of miniCEP290^580–1180. Cep290^rd16 mice subretinally injected at P0/P1 stage with indicated miniCEP290s or GFP were analyzed by (A) scotopic and (B) photopic electroretinogram (ERG) at 3 weeks post injection. Age-matched uninjected WT or Cep290^rd16 (littermates) mice were used as controls for ERG. The ERG a-wave is represented by arrows, while b-wave is depicted using arrowheads. (C) Statistical analysis of the scotopic a- and b-waves and photopic b-wave amplitudes was performed using at least six mice per experiment. ***p < 0.0001. (D) Scotopic (a- and b-waves) and photopic b-wave analysis of the injected mice was performed at 4, 5, and 8 weeks post injection and compared to the ERG amplitudes at 3 weeks post injection. Age-matched uninjected WT, GFP-injected Cep290^rd16, and uninjected Cep290^rd16 mice were used as controls. *p < 0.05; **p < 0.001. Color images available online at www.liebertpub.com/hum