Table 1.
Global gene expression analysis by microarray in purified CD11b+/Gr-1 (‒) peripheral macrophages from WT and ciap1 KO mice.
| (A) CIAP1-KO Vs WT (Naive) | |
|---|---|
| Upregulated | Downregulated |
| TNFR2, INTRINSIC, NO1, VIP, 41BB, TNFR2, ACH, and NKT | PYK2, IL1R, MAL, MITOCHONDRIA, HCMV, IL17, RAS, NEUROTRANSMITTERS, ERYTH, HER2, HCMV, BARR_MAPK, FAS, SARS, and GLYCOLYSIS |
| Positive regulation of ER associated ubiquitin-dependent protein catabolic | Cranial nerve formation |
| Regulation of receptor internalization | |
| Peptidyl asparagine modification | Stress response to metal ion |
| Regulation of cholesterol esterification | Regulation of receptor internalization |
| Positive regulation of cholesterol esterification | Negative regulation of leukocyte adhesion to vascular endothelial cell |
| Protein N-linked glycosylation via asparagine | Regulation of membrane repolarization during action potential |
| Cranial nerve formation | Adenylate cyclase activating G protein-coupled receptor signaling pathway |
| Negative regulation of retrograde protein transport ER to cytosol | DNA replication-dependent nucleosome assembly and organization |
| Negative regulation of protein exit from endoplasmic reticulum | Common myeloid progenitor cell proliferation |
| Positive regulation of regulatory T cell differentiation | Positive regulation of transcription from RNA polymerase III promoter |
| Regulation of NFAT protein import into nucleus | Negative regulation of megakaryocyte differentiation |
| Regulation of cytokine production | Regulation of type B pancreatic cell proliferation |
| Regulation of cytokine biosynthetic process | |
| Regulation of interleukin 2 biosynthetic process | |
| Regulation of immature T cell proliferation in thymus | |
| Serine family amino acid catabolic process | |
| FOA2 and FOA3 transcription factor networks | FOM1 transcription factor network |
| Glucocorticoid receptor regulatory network | EphrinA EPHA pathway |
| Alpha6 beta4 integrin ligand interactions | Non-genotropic androgen signaling |
| Arf6 signaling events | |
| GMCSF-mediated signaling events | |
| IL27-mediated signaling events | |
| Heterotrimeric G protein signaling pathway | X5 hydroxytryptamine degradation |
| Gi alpha- and Gs alpha-mediated pathway | Adrenaline and noradrenaline biosynthesis |
| Heme biosynthesis | |
| Gluconeogenesis | Integrin cell surface interactions |
| Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) | |
| Defective CSF2RA causes SMDP4 | |
| Glyoxylate metabolism and glycine degradation | Clearance of nuclear envelope membranes from chromatin |
| Trafficking of myristoylated proteins to the cilium | MAPK1 ERK2 activa |
| Regulation of beta cell development | Defective CSF2RB causes SMDP5 |
| Anchoring fibril formation | Diseases associated with surfactant metabolism IRAK2-mediated activation of TAK1 complex |
| Formation of ATP by chemiosmotic coupling | |
| Keratan sulfate biosynthesis | |
| (B) CIAP1-KO Vs WT (Th1 primed) | |
| Upregulated | Downregulated |
| SODD, IL15, AMI, INTRINSIC | IL10, AKT, RANKL, Glycolysis, SARS, IL17, RAS, GCR |
| Regulation of protein deubiquitination | Positive regulation of ER-associated ubiquitin-dependent protein catabolic |
| Regulation of receptor internalization | |
| Actin nucleation | Regulation of Golgi inheritance |
| Arp2 3 complex-mediated actin nucleation | Regulation of NFAT protein import into nucleus |
| Chromosome movement toward spindle pole | Positive regulation of regulatory T cell differentiation |
| Cellular response to parathyroid hormone stimulus | Cell adhesion mediated by integrin |
| Meiotic cytokinesis | Cellular amino acid catabolic process |
| Carbon dioxide transport | Pyroptosis |
| Cholesterol homeostasis | Histamine metabolic process |
| Sterol homeostasis | Imidazole containing compound metabolic process |
| Stress response to metal ion | Inflammatory response |
| Positive regulation of deacetylase activity | Positive regulation of plasminogen activation |
| Positive regulation of histone deacetylase activity | DNA dealkylation |
| Sphingoid biosynthetic process | DNA demethylation |
| Cellular modified amino acid catabolic process | |
| Heme transport | |
| Hormone catabolic process | |
| Fructose metabolic process | |
| Alpha6 beta4 integrin ligand interactions | Trk receptor signaling mediated by PI3K and PLC gamma |
| Endogenous TLR signaling | FOA1 transcription factor network |
| Beta2 integrin cell surface interactions | Alpha9 beta1 integrin signaling events |
| Syndecan 4-mediated signaling event | Arf6 signaling events |
| Integrin family cell surface interactions | |
| Inflammation mediated by chemokine and cytokine signaling pathway | N-Acetylglucosamine metabolism |
| Angiogenesis | |
| Vitamin D metabolism and pathway | |
| Gamma aminobutyric acid synthesis | |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | Defective CSF2RA and CSF2RB cause pulmonary surfactant metabolism |
| Diseases associated with surfactant metabolism | |
| Classical Kir channels | |
| Innate immune system | Defective CSF2RB causes SMDP5 |
| Toll-like receptor 3 cascade | Diseases associated with surfactant metabolism |
| MyD88-independent TLR3 TLR4 cascade | Amine-derived hormones |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | VLDL biosynthesis |
| DEx H box helicases activate type I IFN and inflammatory cytokines production | |
| Metallothioneins bind metals, response to metal ions, and classical Kir channels | |