Figure 1.
Heart regenerative capacity in warm- or cold-blooded animals. For each species, cardiac regenerative ability is indicated in green (ability to regenerate), orange (incomplete capacity to regenerate) or red (incapacity to regenerate). In each case, the approach used to induce cardiac damage and the references associated are indicated. In warm-blooded species, cardiac regeneration appears to be restricted to a defined early-developmental period during embryonic and early-neonatal life. In cold-blooded animals, six out of nine species have the ability to regenerate their heart during adult life, whereas three out of nine species show an incomplete capacity or incapacity to undergo heart regeneration.