Table 2.
HLA-DPB1-rs9277534 linkage analysis of 32,681 samples.
Categories were formed on the zygosity of rs9277534 expected from the DPB1 genotyping based on exons 2 and 3 and the presence of a phasing ambiguity between those two exons. Secondary analysis was performed only for samples with an unexpected linkage or otherwise inconclusive results after primary analysis.
| Expected rs9277534 | Ambiguities due to unresolved phasing between exons 2 and 3 | Samples | Unexpected linkages | |
|---|---|---|---|---|
| Primary analysis (amplicons) | Secondary analysis (SMRT) | |||
| Homozygous | Not relevant | 21,322 (59%) | 18 (0.09%) | 1a (0.005%) |
| Heterozygous | No | 7,481 (23%) | 4 (0.05%) | 2a (0.03%) |
| s | Yes | 5,761 (18%) | 0 | 0 |
| Unknown | – | 117 (0.4%) | – | – |
|
| ||||
| total | 32,681 | 22 (0.07%) | 3a (0.01%) | |
a
All remaining unexpected linkages related to DPB1 *34:01.