. 2017 Dec 12;11:702. doi: 10.3389/fnins.2017.00702

Table 2.

Enriched Gene Ontology Terms in the EC of APOE3/4 vs. APOE3/3 mice.

Gene ontology term	Gene ontology database	Number of genes	Percent matched	p-value	FDR
Protein binding	GOTERM_MF_DIRECT	315	28.2	2E-16	2.4E-13
Cytoplasm	GOTERM_CC_DIRECT	430	38.5	1.8E-12	1.1E-09
Cytosol	GOTERM_CC_DIRECT	150	13.4	6.6E-11	2.1E-08
Membrane	GOTERM_CC_DIRECT	439	39.3	1.7E-10	3.6E-08
Extracellular exosome	GOTERM_CC_DIRECT	198	17.7	1.9E-09	3E-07
Mitochondrion	GOTERM_CC_DIRECT	134	12	9.5E-08	0.000012
Cytoplasmic vesicle membrane	GOTERM_CC_DIRECT	22	2	3.8E-07	0.00004
Cell junction	GOTERM_CC_DIRECT	67	6	0.0000008	0.000071
Myelin sheath	GOTERM_CC_DIRECT	27	2.4	0.0000029	0.00022
Transport	GOTERM_BP_DIRECT	141	12.6	0.0000003	0.0011
Focal adhesion	GOTERM_CC_DIRECT	40	3.6	0.000024	0.0017
Axon	GOTERM_CC_DIRECT	38	3.4	0.000037	0.0021
Lysosomal membrane	GOTERM_CC_DIRECT	28	2.5	0.000036	0.0023
Neuron projection	GOTERM_CC_DIRECT	40	3.6	0.00012	0.0052
Golgi membrane	GOTERM_CC_DIRECT	39	3.5	0.0001	0.0053
SNARE complex	GOTERM_CC_DIRECT	11	1	0.00011	0.0055
Endosome	GOTERM_CC_DIRECT	48	4.3	0.00014	0.0058
Cytoskeleton	GOTERM_CC_DIRECT	82	7.3	0.00027	0.01
Nucleoplasm	GOTERM_CC_DIRECT	129	11.6	0.00032	0.012
Perinuclear region of cytoplasm	GOTERM_CC_DIRECT	56	5	0.00034	0.012
Cell surface	GOTERM_CC_DIRECT	51	4.6	0.00061	0.02
Vesicle	GOTERM_CC_DIRECT	19	1.7	0.0012	0.038
Melanosome	GOTERM_CC_DIRECT	14	1.3	0.0014	0.038
Synaptic vesicle	GOTERM_CC_DIRECT	16	1.4	0.0014	0.04
Rhythmic process	GOTERM_BP_DIRECT	20	1.8	0.000025	0.043
Postsynaptic density	GOTERM_CC_DIRECT	24	2.2	0.0017	0.044
Centrosome	GOTERM_CC_DIRECT	37	3.3	0.0017	0.046

All GO terms enriched in the APOE3/4 vs. APOE3/3 EC that possessed a false discovery rate (FDR) of less than 0.05, with additional information on the GO database they were found in, the number of genes that were found from each GO term and the percent of genes that were matched for each GO term (GO terms directly related to the endosomal–lysosomal system are in bold).