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. 2017 Dec 4;214(12):3611–3626. doi: 10.1084/jem.20171749

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© 2017 Swanson et al.

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Figure 2. — cGAMP induces AIM2-NLRP3-ASC inflammasome. IL-1β ELISAs from supernatants of LPS-primed BMDMs transfected with the indicated PAMP or DAMP. BMDMs were obtained from WT or Aim2^−/− (a), Nlrp3^−/− (b), Asc^−/− (c), Casp1^−/− (d), Nlrc4^−/− (e), and Casp11^−/− and Ice^−/− (f). NT, not transfected with PAMP; TFXN, transfected with transfection reagent only. n = 3 independent experiments ± SEM. **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.