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. 2017 Dec 4;214(12):3611–3626. doi: 10.1084/jem.20171749

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© 2017 Swanson et al.

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Figure 1. — cGAMP induces inflammasome activation. (a and b) IFN-β (a) and IL-1β (b) ELISAs of BMDM supernatants primed with LPS then transfected with various dosages of cGAMP (n = 3 independent experiments, mean ± SEM). (c) Western blots of supernatants and cell lysates from b. (d) IL-18 ELISA of BMDMs treated as described in a. (e–g) ELISAs of primary human macrophages (e and f) and human DCs (g) treated as depicted for BMDMs (individual donors ± SD). casp-1, caspase-1; Mφ, macrophage, NT, not transfected with PAMP; Tfxn, transfected with transfection reagent only. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. Results shown in a, b, and d are combined from three independent experiments and are presented as the mean ± SEM.