Figure 6. CERES reduces false positives among lineage-specific differential dependencies due to recurrently amplified chromosome arms.
(a) The distributions of differential dependencies in breast lines are plotted red for genes on chromosome 8q (commonly gained in breast tumors) and black for all other genes. Below, the differential dependency of each gene is plotted against the FDR-corrected p-value, calculated from a student’s t-test, with colors as above. The dashed line represents an FDR of 5%. (b) Data are shown for CERES-inferred gene effects as in (a). (c) The percentages of lineage-specific differential dependencies (FDR < 0.05) that are on recurrently amplified chromosome arms are shown, before and after CERES correction.