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. 2017 Nov 28;7:16533. doi: 10.1038/s41598-017-15813-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reduced innate immune response following P-PFF treatments in vivo. (a) Cells obtained from ipsilateral striatal tissue of 3 dpi injected mice were stained and analyzed by flow-cytometry. Each animal was analyzed individually. Representative FACS plots showing the percentages of CD11b⁺ cells gated on CD45^high leukocytes. (b) Cumulative data showing the percentages of CD45^highCD11b⁺ macrophages in injected animals. Data are pooled from three independent experiments. (c) TNF-α (d) INF-γ and (e) IL-10 levels were measured in ipsilateral striatum homogenates by ELISA. Data are expressed as mean ± SEM of triplicate wells. Data shown for cytokine release are pooled from three independent experiments. Statistical significance was obtained by ANOVA followed by Tukey’s post-hoc test. (b) p < 0,0001 (c) p = 0,0007 (e) p = 0,0001.