Figure 8. Human alternative proteome sequence analysis and classification using InterProScan.
(a) InterPro annotation pipeline. (b) Alternative and reference proteins with InterPro signatures. (c) Number of alternative and reference proteins with transmembrane domains (TM), signal peptides (S) and both TM and SP. (d) Number of all alternative and reference proteins predicted to be intracellular, membrane, secreted and membrane-spanning and secreted (Ingolia et al., 2011). Proteins with at least one InterPro signature (Lee et al., 2012); proteins with no predicted signal peptide or transmembrane features. (e) Number of predicted TM regions for alternative and reference proteins.
Figure 8—figure supplement 1. Alternative proteome sequence analysis and classification in P. troglodytes, M. musculus, B. Taurus, D. melanogaster and S. cerevisiae.
For each organism, the number of InterPro signatures (top graphs) and proteins with transmembrane (TM), signal peptide (SP), or TM +SP features (bottom pie charts) is indicated for alternative and reference proteins.
Figure 8—figure supplement 1—source data 1. Alternative proteome sequence analysis and classification in P. troglodytes, M. musculus, B. Taurus, D. melanogaster and S. cerevisiae.
elife-27860-fig8-figsupp1-data1.xlsx (9.5KB, xlsx)
DOI: 10.7554/eLife.27860.028