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. 2017 Nov 20;8:327. doi: 10.3389/fendo.2017.00327

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Copyright © 2017 Pereira, Gohin, Roux, Fisher, Cleasby, Mabilleau and Chenu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Exenatide on bone turnover parameters in db/db and control mice. Measurements were performed by bone histomorphometry on the trabecular region of tibial sections from 13-week-old db/db and lean mice treated with either Exenatide (10 μg/kg/day) or saline. (A) Bone formation rate (BFR). (B) Mineral apposition rate (MAR). (C) Mineralizing surfaces MS/BS. (D) Tartrate-resistant acid phosphatase (TRAP)-positive osteoclastic surfaces per millimeter of trabecular bone surface. Bars represent mean ± SD of n = 10 mice/group, **P < 0.01, ***P < 0.001, ****P < 0.0001 versus lean Sal; ^##P < 0.01, ^###P < 0.001 versus diabetic Sal.