Figure 3.
Delivery of circ-Amotl1 attenuated Dox-induced cardiomyopathy in mice (a) Representative echocardiography photographs showing heart function in different groups. (b) Dox treatment decreased mouse LVEDD-LVESD. Ectopic expression of circ-Amotl1 reversed Dox-induced effect (Error bars, SD, n=10 mice). (c-i) Dox treatment reduced mouse Ejection fraction (EF, c), Fractional shortening (FS, d), Left ventricular posterior wall (LVPW, e), Left ventricular pressure (LVP, f), Ratio of heart weight and body weight (HW/BW g), Left ventricular contractility dP/dt (max, h), and dP/dt (min, i). Ectopic expression of circ-Amotl1 reversed these effects. (Error bars, SD, n=10 mice).