| Nomenclature | phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit alpha | phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit beta |
| HGNC, UniProt | PIK3CA, P42336 | PIK3CB, P42338 |
| EC number | 2.7.1.153 2.7.11.1 | 2.7.1.153 |
| Common abreviation | PI3Kα | PI3Kβ |
| Inhibitors | PIK‐75 (pIC50 9.5) [213], gedatolisib (pIC50 9.4) [544], PF‐04691502 (pK i 9.2) [309], PI‐103 (pIC50 8.7) [435], BGT‐226 (pIC50 8.4) [337], KU‐0060648 (pIC50 8.4) [66], dactolisib (pIC50 8.4) [332], apitolisib (pIC50 8.3) [506] | KU‐0060648 (pIC50 9.3) [66], PI‐103 (pIC50 8.5) [435], AZD6482 (pIC50 8) [380], ZSTK474 (pIC50 7.4–7.8) [578, 583], apitolisib (pIC50 7.6) [506], BGT‐226 (pIC50 7.2) [337] |
| Sub/family‐selective inhibitors | pictilisib (pIC50 8.5) [149] | pictilisib (pIC50 7.5) [149] |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.