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. 2017 Oct 21;174(Suppl Suppl 1):S272–S359. doi: 10.1111/bph.13877
Nomenclature PLD1 PLD2
HGNC, UniProt PLD1, Q13393 PLD2, O14939
EC number 3.1.4.4 3.1.4.4 A phosphatidylcholine + H2O <=> choline + a phosphatidate
Endogenous activators ADP‐ribosylation factor 1 (ARF1, P84077), PIP2, RhoA, PKC evoked phosphorylation, RalA [201, 323] ADP‐ribosylation factor 1 (ARF1, P84077), PIP2 [316], oleic acid [454]
Endogenous inhibitors Gβ γ [418] Gβ γ [418]
Inhibitors FIPI (pIC50 8) [463] FIPI (pIC50 7.8) [484]
Selective inhibitors compound 69 (pIC50 7.3) [463] VU0364739 (pIC50 7.7) [293]