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. 2017 Oct 21;174(Suppl Suppl 1):S272–S359. doi: 10.1111/bph.13877
Nomenclature aldehyde dehydrogenase 9 family member A1 4‐aminobutyrate aminotransferase aldehyde dehydrogenase 5 family member A1
HGNC, UniProt ALDH9A1, P49189 ABAT, P80404 ALDH5A1, P51649
EC number 1.2.1.19: 4‐aminobutanal + NAD + H2O = GABA + NADH + H+ 1.2.1.47: 4‐trimethylammoniobutanal + NAD + H2O = 4‐trimethylammoniobutanoate + NADPH + 2H+ 1.2.1.3: an aldehyde + H2O + NAD = a carboxylate + 2H+ + NADH 2.6.1.19: GABA + α‐ketoglutaric acid = L‐glutamic acid + 4‐oxobutanoate 2.6.1.22: (S)‐3‐amino‐2‐methylpropanoate + α‐ketoglutaric acid = 2‐methyl‐3‐oxopropanoate + L‐glutamic acid 1.2.1.24: 4‐oxobutanoate + NAD + H2O = succinic acid + NADH + 2H+ 4‐hydroxy‐trans‐2‐nonenal + NAD + H2O = 4‐hydroxy‐trans‐2‐nonenoate + NADH + 2H+
Common abreviation – GABA‐T SSADH
Cofactors NAD pyridoxal phosphate NAD [469]
Inhibitors – vigabatrin (Irreversible inhibition) (pK i 3.1) [306, 475] 4‐acryloylphenol (pIC50 6.5) [519]