| Nomenclature | Glutamic acid decarboxylase 1 | Glutamic acid decarboxylase 2 |
| HGNC, UniProt | GAD1, Q99259 | GAD2, Q05329 |
| EC number | 4.1.1.15: L‐glutamic acid + H+ ‐>GABA + CO2 | 4.1.1.15: L‐glutamic acid + H+ ‐>GABA + CO2 |
| Common abreviation | GAD1 | GAD2 |
| Endogenous substrates | L‐glutamic acid, L‐aspartic acid | L‐glutamic acid, L‐aspartic acid |
| Products | GABA | GABA |
| Cofactors | pyridoxal phosphate | pyridoxal phosphate |
| Selective inhibitors | s‐allylglycine | s‐allylglycine |
| Comments | L‐aspartic acid is a less rapidly metabolised substrate of mouse brain glutamic acid decarboxylase generating β‐alanine [577]. Autoantibodies against GAD1 and GAD2 are elevated in type 1 diabetes mellitus and neurological disorders (see Further reading). |
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