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. 2017 Oct 21;174(Suppl Suppl 1):S272–S359. doi: 10.1111/bph.13877
Nomenclature CYP5A1 CYP7A1 CYP7B1 CYP8A1 CYP8B1
HGNC, UniProt TBXAS1, P24557 CYP7A1, P22680 CYP7B1, O75881 PTGIS, Q16647 CYP8B1, Q9UNU6
EC number 5.3.99.5: PGH2 = thromboxane A2 1.14.13.17 1.14.13.100 5.3.99.4 1.14.13.95
Common name Thromboxane synthase – – Prostacyclin synthase –
Comments Inhibited by dazoxiben [427] and camonagrel [194]. Converts cholesterol to 7α‐hydroxycholesterol [379]. Converts dehydroepiandrosterone to 7α‐DHEA [445]. Converts PGH2 to PGI2 [209]. Inhibited by tranylcypromine [193] Converts 7α‐hydroxycholest‐4‐en‐3‐one to 7‐alpha,12α‐dihydroxycholest‐4‐en‐3‐one (in rabbit) [239] in the biosynthesis of bile acids.