| Nomenclature | ASIC3 |
| HGNC, UniProt | ASIC3, Q9UHC3 |
| Endogenous activators | Extracellular H+ (transient component) (pEC50∼6.2–6.7), Extracellular H+ (sustained component) (pEC50∼3.5–4.3) |
| Activators | GMQ (largly non‐desensitizing; at pH 7.4) (pEC50∼3), arcaine (at pH 7.4) (pEC50∼2.9), agmatine (at pH 7.4) (pEC50∼2) |
| Channel blockers | APETx2 (transient component only) (pIC50 7.2), nafamostat (transient component) (pIC50∼5.6), A‐317567 (pIC50∼5), amiloride (transient component only ‐ sustained component enhanced by 200μM amiloride at pH 4) (pIC50 4.2–4.8), Gd3+ (pIC50 4.4), Zn2+ (pIC50 4.2), aspirin (sustained component) (pIC50 4) [372], diclofenac (sustained component) (pIC50 4), salicylic acid (sustained component) (pIC50 3.6) |
| Functional Characteristics | γ ~ 13‐15 pS; biphasic response consisting of rapidly inactivating transient and sustained components; very rapid activation (<5 ms) and inactivation (0.4 s); fast recovery (0.4‐0.6 s) @ pH 7.4, transient component partially inactivated at pH 7.2 |
| Comments | ASIC3 is also blocked by diarylamidines |
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