Extended Data Table 1.
Genetic alterations of the CRC patient sample
| Alterations | Gene Name | DNA change | Protein change |
|---|---|---|---|
| Missense Mutation | BRAF (NM_004333) | c.1397G>T | p.G466V |
| TP53 (NM_000546) | c.481G>T | p.A161S | |
| APC (NM_000038) | c.4461_4464delTATT | p.L1488fs | |
| c.2379_2380delAA | p.S794fs | ||
| BARD1 (NM_000465) | c.709C>T | p.Q237X | |
| FLCN (NM_144997) | c.323G>T | p.S108I | |
| LATS1 (NM_004690) | c.860G>A | p.R287Q | |
| MITF (NM_198159) | c.5A>C | p.Q2P | |
| MYCL1 (NM_001033082) | c.128A>G | p.Y43C | |
| Gene Deletion | TGFBR2 (NM_001024847) | deletion | Reduced expression |
| MAP2K4 (NM_003010) | Intragenic deletion | Reduced expression | |
| PARK2 (NM_004562) | Intragenic deletion | Reduced expression | |
| PIK3R1 (NM_181523) | Intragenic deletion | Reduced expression |