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. 2017 Jul 10;8(38):63857–63870. doi: 10.18632/oncotarget.19148

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Copyright: © 2017 Wu et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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(A) The knockdown efficiencies of three shRNAs targeting PTN were examined in MG63 (upper) and MG63/DOX (lower) cells by Western blotting. (B) The overexpression efficiency of the plasmid was examined in MG63 (upper) and MG63/DOX (lower) cells by Western blotting. (C, D) PTN knockdown prevented DOX resistance in MG63 (C) and MG63/DOX (D) cells, while supplementation with rhPTN for 24 h (100 ng/mL) could reverse this effect. (E) PTN overexpression promoted DOX resistance in MG63 cells. *p < 0.05. PTN: pleiotrophin; OS: osteosarcoma; DOX: doxorubicin; rhPTN: recombinant human pleiotrophin; sh: short hairpin; oe: overexpression.